| Number | Service (From/To) | General Details | | 250 | Birkenshaw (near Larkhall) to East Kilbride | Mon to Sat (every 60 mins) |
| Via Larkhall-Hareleeshill-Allanton-Ferniegair-Hamilton-Bus Station ..... more |
| | Birkenshaw (near Larkhall) to Hamilton | Mon to Sat (every 60 mins) |
| Via Larkhall-Hareleeshill-Larkhall-Hareleeshill-Allanton ..... more |
| 253 | Coalburn to Hamilton | Only this direction, Mon to Sat (14 trips) |
| Via Lesmahagow-Tesco-Kirkmuirhill-Blackwood-Canderside Toll ..... more |
| | Coalburn to Hamilton | Evenings/Sun only, one way, Mon to Sat (4 trips) Sun (every 60 mins) |
| Via Lesmahagow-Woodpark-Lesmahagow (Tesco)-Kirkmuirhill-Blackwood ..... more |
| | Coalburn to Hareleeshill | Only this direction, Mon to Sat (1 trip) |
| Via Lesmahagow-Tesco-Kirkmuirhill-Blackwood-Canderside Toll ..... more |
| | Coalburn to Wishaw (General Hospital) | Only this direction, Mon to Fri (9 trips) Sat (7 trips) |
| Via Lesmahagow-Tesco-Kirkmuirhill-Blackwood-Canderside Toll ..... more |
| | Hamilton to Coalburn | Evenings/Sun only, one way, Mon to Sat (4 trips) Sun (every 60 mins) |
| Via Hamilton-Ferniegair-Allanton-Hareleeshill-Larkhall-Canderside Toll ..... more |
| | Hamilton to Coalburn | Only this direction, Mon to Sat (14 trips) |
| Via Hamilton-Ferniegair-Allanton-Hareleeshill-Larkhall-Canderside Toll ..... more |
| | Wishaw (General Hospital) to Coalburn | Only this direction, Mon to Fri (9 trips) Sat (7 trips) |
| Via Wishaw-Netherton-Motherwell-Muirhouse-Flemington-Motherwell (ASDA) ..... more |
| 254 | Hairmyres (Hospital) to Strathaven | Mon to Sat (3 trips) |
| Via Hairmyres-East Kilbride (Westwood)-East Kilbride (Bus Station) ..... more |
| | Hamilton to Stonehouse | Mon to Fri (12 trips, -60 back) Sat (13 trips, -60 back) |
| Via Hamilton-Ferniegair-Allanton-Hareleeshill-Larkhall-Canderside Toll |
| | Hamilton to Strathaven | Mon to Fri (9 trips, 8 back) Sat (7 trips, 8 back) Sun (13 trips, -60 back) |
| Via Hamilton-Ferniegair-Allanton-Hareleeshill-Larkhall-Canderside Toll ..... more |
| | Stonehouse to Hairmyres (Hospital) | Mon to Fri (9 trips) Sat (every 60 mins) |
| Via Canderside Toll-Larkhall-Hareleeshill-Allanton-Ferniegair ..... more |
| | Stonehouse to Strathaven | Only this direction, Sat (2 trips) |
| | Strathaven to Larkhall | Evenings only, one way, Mon to Sun (1 trip) |
| Via Stonehouse-Canderside Toll |
| 255 | Netherburn to Hamilton | Mon to Sun (every 60 mins) |
| Via Ashgill-Shawsburn-Hareleeshill-Larkhall-Hareleeshill ..... more |
| 256 | Hamilton to East Kilbride | Mon to Sat (8 trips) |
| Via Hamilton-Low Waters-Cadzow-Eddlewood-Quarter-Limekilnburn ..... more |
| | Strathaven to East Kilbride | Mon to Sat (2 trips) |
| Via Chapelton-Kelvin-East Kilbride (Whitehills)-Greenhills ..... more |
| | Strathaven to Hamilton | Mon to Sat (2 trips) |
| Via Glassford-Limekilnburn-Quarter-Eddlewood-Cadzow-Low Waters ..... more |
| 258 | Lanark to Lesmahagow | Only this direction, Mon to Sat (4 trips) |
| Via Lanark-Kirkfieldbank-Auchenheath-Kirkmuirhill-Lesmahagow ..... more |
| | Lanark to Lesmahagow | Only this direction, Mon to Sat (4 trips) |
| Via Lanark-Kirkfieldbank-Auchenheath-Kirkmuirhill |
| | Lesmahagow to Lanark | Only this direction, Mon to Sat (5 trips) |
| Via Lesmahagow (Woodpark)-Lesmahagow-Tesco-Kirkmuirhill-Auchenheath ..... more |
| | Lesmahagow to Lanark | Only this direction, Mon to Sat (3 trips) |
| Via Lesmahagow (Tesco)-Kirkmuirhill-Auchenheath-Kirkfieldbank ..... more |
| 259 | Glespin (Stablestone Primary School) to Lanark | Mon to Sat (3 trips) |
| Via Glespin-Douglas-Lady Home Cottage Hospital-Douglas-Uddington ..... more |
| | Lanark to Glespin (Stablestone Primary School) | Mon to Sat (4 trips) |
| Via Lanark-Hyndford Bridge-Rigside-Uddington-Douglas-Lady Home Cottage Hospital ..... more |